Current And Future Ad Drug Development Associated Obstacles

Current Future AD Drug Development Associated Obstacles With 46.8 million people currently living with AD and the number of people to be diagnosed in the future set to rise, a study conducted by (Cummings, Morstorf Zhong 2014) analysed the clinical trials associated with Alzheimer’s drug development throughout 2002 to 2012 in USA listed on clinicaltrials.gov. The united states undertakes the largest number of clinical trials compared to anywhere else in the world; in total 413 trials had and are being undertaken (Phase I-124, Pahse2-206, Phase 3- 83), but it was found that this number is relatively low in terms of addressing the magnitude of the problem with roughly 131.5 million people worldwide set to have AD by 2050 (Cummings, Morstorf Zhong 2014; Prince et al. 2015). Figure 3 depicts the different therapeutic pathway being focused on; with 36.5% of trials investigating the development of symptomatic agents and 35.1% focusing on disease-modifying small molecules, with the remaining 23% focusing on immunotherapies, therapeutic devices and stem cell research. Throughout the past decade 244 agents in the United States alone were proposed for marketing, with only one being approved, memantine, indicating a success rate of only 0.4%, the lowest out of any therapeutic industry. The study also identified the fail rate for each stage of clinical trials; was extremely high, decreasing the likelihood of drug progressing to the next stage (Cummings, Morstorf ZhongShow MoreRelatedThe Dangers Of Adolescent Smoking Essay1140 Words   |  5 Pagesthe total number of residents calculated by age and gender was reaching 97 thousand residents—96,701 to be exact (Current, 2016). 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